Article
Molecular and phenotypic analysis of mutations causing anionic phospholipid deficiency in closely related yeast species.
Folia microbiologica - 1 Jan 2009
Batová M, Dzugasová V, Borecká S, Goffa E, Oblasová Z, Subík J
Abstract excerpt
The pel1 mutation in Saccharomyces cerevisiae and the Cgpgs1Delta mutation in Candida glabrata result in deficiency of mitochondrial phosphatidylglycerolphosphate synthase and lack of two anionic phospholipids, phosphatidylglycerol and cardiolipin. DNA sequence analysis of the PCR-amplified pel1 mutant allele revealed that the pel1 mutation resulted from a single amino-acid substitution (Glu(463)Lys) in the...
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