Article
Functional analysis of the phospholipase C gene CaPLC1 and two unusual phospholipase C genes, CaPLC2 and CaPLC3, of Candida albicans.
Microbiology (Reading, England) - 1 Oct 2005
Kunze Donika, Melzer Inga, Bennett Désirée, Sanglard Dominique, MacCallum Donna, Nörskau Jan, Coleman David C, Odds Frank C, Schäfer Wilhelm, Hube Bernhard
Abstract excerpt
Phospholipases C are known to be important regulators of cellular processes but may also act as virulence factors of pathogenic microbes. At least three genes in the genome of the human-pathogenic fungus Candida albicans encode phospholipases with conserved phospholipase C (Plc) motifs. None of the deduced protein sequences contain N-terminal signal peptides, suggesting that these phospholipases are not secreted....
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