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Article

Loss of function of KRE5 suppresses temperature sensitivity of mutants lacking mitochondrial anionic lipids.

Molecular biology of the cell - 1 Feb 2005

Zhong Quan, Gvozdenovic-Jeremic Jelena, Webster Paul, Zhou Jingming, Greenberg Miriam L

Abstract excerpt

Disruption of PGS1, which encodes the enzyme that catalyzes the committed step of cardiolipin (CL) synthesis, results in loss of the mitochondrial anionic phospholipids phosphatidylglycerol (PG) and CL. The pgs1Delta mutant exhibits severe growth defects at 37 degrees C. To understand the essential functions of mitochondrial anionic lipids at elevated temperatures, we isolated suppressors of pgs1Delta that grew...

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Identifiers

PMID: 15563612
DOI: 10.1091/mbc.e04-09-0808
PMCID: PMC545902

Genes

PGS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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