Article
Yeast Pgc1p (YPL206c) controls the amount of phosphatidylglycerol via a phospholipase C-type degradation mechanism.
The Journal of biological chemistry - 20 Jun 2008
Simocková Mária, Holic Roman, Tahotná Dana, Patton-Vogt Jana, Griac Peter
Abstract excerpt
The product of the open reading frame YPL206c, Pgc1p, of the yeast Saccharomyces cerevisiae displays homology to bacterial and mammalian glycerophosphodiester phosphodiesterases. Deletion of PGC1 causes an accumulation of the anionic phospholipid, phosphatidylglycerol (PG), especially under conditions of inositol limitation. This PG accumulation was not caused by increased production of phosphatidyl-glycerol...
Topics
- Amino Acid Sequence
- Cardiolipins
- DNA, Fungal
- Gene Expression Regulation
- Gene Expression Regulation, Fungal
- Inositol
- Mitochondria
- Models, Biological
- Molecular Sequence Data
- Mutation
- Phosphatidylglycerols
- Phospholipids
- Phosphoric Diester Hydrolases