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Article

Chd5 requires PHD-mediated histone 3 binding for tumor suppression.

Cell reports - 31 Jan 2013

Paul Shilpi, Kuo Alex, Schalch Thomas, Vogel Hannes, Joshua-Tor Leemor, McCombie W Richard, Gozani Or, Hammell Molly, Mills Alea A

Abstract excerpt

Chromodomain Helicase DNA binding protein 5 (CHD5) is a tumor suppressor mapping to 1p36, a genomic region that is frequently deleted in human cancer. Although CHD5 belongs to the CHD family of chromatin-remodeling proteins, whether its tumor-suppressive role involves an interaction with chromatin is unknown. Here we report that Chd5 binds the unmodified N terminus of H3 through its tandem plant homeodomains...

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Identifiers

PMID: 23318260
DOI: 10.1016/j.celrep.2012.12.009
PMCID: PMC3575599

Genes

CHD5

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Chd5 requires PHD-mediated histone 3 binding for tumor suppression.PMID 23318260Read ↗

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The therapeutic potential of targeting the CHD protein family in cancer.Semantic proximity Read ↗

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Mechanisms of CHD5 Inactivation in NeuroblastomasSemantic proximity Read ↗

Expression of the neuron-specific protein CHD5 is an independent marker of outcome in neuroblastomaSemantic proximity Read ↗

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