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Article

Chromatin as a target antigen in human and murine lupus nephritis

1 Jan 2011

Abstract excerpt

The present review focuses on pathogenic molecular and transcriptional events in patients with lupus nephritis. These factors are renal DNaseI, exposed chromatin fragments and the corresponding chromatin-reactive autoantibodies. Lupus nephritis is the most serious complication in human systemic lupus erythematosus, and is characterised by deposition of chromatin fragment-IgG complexes in the mesangial matrix and...

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PMID: 21542875
DOI: 10.1186/ar3281

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