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Article

Pathogenesis of lupus nephritis: An update

1 Apr 2005

Abstract excerpt

Lupus nephritis (LN) is a prototypic autoimmune disease. Its immunopathogenesis is characterized by the loss of self-tolerance. In this article, we review our current understanding of the disease mediators of LN. There is ample evidence to suggest a pathogenic role of nephritogenic autoantibodies. These antibodies cross react with nucleosomal epitopes, and the in vivo generation of nucleosomes requires apoptosis....

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PMID: 15877678
DOI: 10.1111/j.1440-1797.2005.00392.x

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