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Article

Evidence of ultraviolet type mutations in xeroderma pigmentosum melanomas.

Proceedings of the National Academy of Sciences of the United States of America - 14 Apr 2009

Wang Yun, Digiovanna John J, Stern Jere B, Hornyak Thomas J, Raffeld Mark, Khan Sikandar G, Oh Kyu-Seon, Hollander M Christine, Dennis Philip A, Kraemer Kenneth H

Abstract excerpt

To look for a direct role of ultraviolet radiation (UV) exposure in cutaneous melanoma induction, we studied xeroderma pigmentosum (XP) patients who have defective DNA repair resulting in a 1000-fold increase in melanoma risk. These XP melanomas have the same anatomic distribution as melanomas in the general population. We analyzed laser capture microdissection samples of skin melanomas from XP patients studied...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19329485
DOI: 10.1073/pnas.0812401106
PMCID: PMC2669353

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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