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Article

High frequency of PTEN mutations in nevi and melanomas from xeroderma pigmentosum patients.

Pigment cell & melanoma research - 1 May 2014

Masaki Taro, Wang Yun, DiGiovanna John J, Khan Sikandar G, Raffeld Mark, Beltaifa Senda, Hornyak Thomas J, Darling Thomas N, Lee Chyi-Chia R, Kraemer Kenneth H

Abstract excerpt

We examined nevi and melanomas in 10 xeroderma pigmentosum (XP) patients with defective DNA repair. The lesions had a lentiginous appearance with markedly increased numbers of melanocytes. Using laser capture microdissection, we performed DNA sequencing of 18 benign and atypical nevi and 75 melanomas (melanoma in situ and invasive melanomas). The nevi had a similar high frequency of PTEN mutations as melanomas...

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Share to GTP Phosphohydrolases
Share to Neoplasms, Radiation-Induced

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Precancerous Conditions

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Source

Open in PubMed Open full text

Identifiers

PMID: 24483290
DOI: 10.1111/pcmr.12226
PMCID: PMC6309892

Genes

PTEN
BRAF
KIT
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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