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Article

Changes in Presenilin 1 gene methylation pattern in diet-induced B vitamin deficiency.

Neurobiology of aging - 1 Feb 2011

Fuso Andrea, Nicolia Vincenzina, Pasqualato Alessia, Fiorenza Maria Teresa, Cavallaro Rosaria A, Scarpa Sigfrido

Abstract excerpt

We have previously shown that a nutritional model of B vitamin deficiency and homocysteine cycle alteration could lead to increased amyloid β deposition, due to PSEN1 and BACE over-expression and consequent increase in secretase activity. We hypothesize that nutritional factors causing homocysteine cycle alterations (i.e. hyperhomocysteinemia) could induce sequence-specific DNA hypomethylation and "aberrant" gene...

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Source

Identifiers

PMID: 19329227
DOI: 10.1016/j.neurobiolaging.2009.02.013

Genes

PSEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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