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Article

Presenilin 1 gene silencing by <i>S</i> ‐adenosylmethionine: a treatment for Alzheimer disease?

2 Apr 2003

Abstract excerpt

Presenilin 1 (PS1) is a key factor for beta-amyloid (Ab) formation in Alzheimer disease (AD). Homocysteine accumulation, frequently observed in AD patients, may be a sign of a metabolic alteration in the S-adenosylmethionine (SAM) cycle, which generates the overexpression of genes controlled by methylation of their promoters, when the cytosine in CpG moieties becomes unmethylated. The methylation of a gene...

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PMID: 12706835
DOI: 10.1016/s0014-5793(03)00277-1

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