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Article

γ-Secretase is Differentially Modulated by Alterations of Homocysteine Cycle in Neuroblastoma and Glioblastoma Cells

29 May 2007

Abstract excerpt

Multiple aspects of homocysteine metabolism were studied to understand the mechanism responsible for hyperhomocysteinemia toxicity in Alzheimer disease. Besides oxidative stress and vascular damage, homocysteine has also a great importance in regulating DNA methylation through S-adenosylmethionine, the main methyl donor in eukaryotes. Alterations of S-adenosylmethionine and methylation were evidenced in Alzheimer...

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PMID: 17851177
DOI: 10.3233/jad-2007-11303

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