Article
Prenatal diagnosis of neonatal alloimmune thrombocytopenia using allele-specific oligonucleotide probes.
Blood - 1 Nov 1991
McFarland J G, Aster R H, Bussel J B, Gianopoulos J G, Derbes R S, Newman P J
Abstract excerpt
The prediction of neonatal alloimmune thrombocytopenia (NATP) in affected families has, in the past, been based on information about gene frequencies of the antigen systems involved, parental phenotyping, and fetal platelet counts. We explored the feasibility of allele-specific oligonucleotide probe typing for PIA antigens to determine the risk of second or subsequent fetuses in families where one infant had a...
Topics
- Adult
- Alleles
- Antibodies
- Antigens, Human Platelet
- Base Sequence
- Blood Platelets
- Female
- Humans
- Immunoglobulin Allotypes
- Infant, Newborn
- Integrin beta3
- Molecular Sequence Data