Article
The prenatal identification of fetal compatibility in neonatal alloimmune thrombocytopenia using amniotic fluid and variable number of tandem repeat (VNTR) analysis.
British journal of haematology - 1 Nov 1995
Denomme G A, Waye J S, Burrows R F, Hayward C P, Warkentin T E, Horsewood P, Smith J W, Jelsema R D, Zuidema L J, Kelton J G
Abstract excerpt
Most severe episodes of neonatal alloimmune thrombocytopenic purpura (NATP) are caused by antiplatelet alloantibodies against the HPA-1a (PlA1) antigen. However, half of subsequent fetuses produced from a HPA-1a/b father (genotypic frequency 28%) will result in a child who is not affected. Some investigators manage NATP by confirming the fetal platelet phenotype using percutaneous umbilical cord sampling, a...
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