Article
Human platelet antigen-1 (Zw) typing of fetuses by analysis of polymerase chain reaction-amplified genomic DNA from amniocytes.
Transfusion medicine (Oxford, England) - 1 Mar 1994
Simsek S, Christiaens G C, Kanhai H H, Beekhuis J R, Bleeker P M, Vlekke A B, Goldschmeding R, von dem Borne A E
Abstract excerpt
Prenatal typing for the human platelet antigens-1 (HPA) permits identification of a fetus at risk for neonatal alloimmune thrombocytopenia (NAITP) in cases of HPA-1 incompatibility in which the father is heterozygous for the HPA-1a antigen. Diagnostic cordocentesis and phenotyping of the fetal pl...
Topics
- Alleles
- Amniocentesis
- Amniotic Fluid
- Antigens, Human Platelet
- Blood Grouping and Crossmatching
- Cells, Cultured
- Cordocentesis
- DNA
- Deoxyribonuclease HpaII
- Deoxyribonucleases, Type II Site-Specific
- Female
- Fetal Blood
- Humans
- Immunization
- Integrin beta3
- Isoantibodies
- Male
- Pedigree