Article
Noninvasive fetal genotyping of human platelet antigen-1a using targeted massively parallel sequencing.
Transfusion - 1 Jun 2015
Wienzek-Lischka Sandra, Krautwurst Annika, Fröhner Vanessa, Hackstein Holger, Gattenlöhner Stefan, Bräuninger Andreas, Axt-Fliedner Roland, Degenhardt Jan, Deisting Christina, Santoso Sentot, Sachs Ulrich J, Bein Gregor
Abstract excerpt
BACKGROUND: Fetal human platelet antigen (HPA) genotyping is required to determine whether the fetus is at risk and whether prenatal interventions to prevent fetal bleeding are required in pregnant women with a history of fetal and neonatal alloimmune thrombocytopenia (FNAIT). Methods for noninvasive genotyping of HPA alleles with the use of maternal plasma cell-free DNA were published recently but do lack...
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