Article
Prediction of fetal blood group and platelet antigens from maternal plasma using next-generation sequencing.
Transfusion - 1 Mar 2019
Orzińska Agnieszka, Guz Katarzyna, Mikula Michal, Kluska Anna, Balabas Aneta, Ostrowski Jerzy, Uhrynowska Małgorzata, Kopeć Izabella, Dębska Marzena, Luterek Katarzyna, Brojer Ewa
Abstract excerpt
BACKGROUND: Fetuses whose mothers have produced antibodies to red blood cell (RBC) or platelet antigens are at risk of being affected by hemolytic disease or alloimmune thrombocytopenia, respectively, only if they inherit the incompatible antigen. Noninvasive diagnosis of the fetal antigen is employed for management of immunized pregnancies, but the specific detection of SNPs, encoding the majority of antigens,...
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