Article
Cigarette smoking and K-ras mutations in pancreas, lung and colorectal adenocarcinomas: etiopathogenic similarities, differences and paradoxes.
Mutation research - 1 Jan 2000
Porta Miquel, Crous-Bou Marta, Wark Petra A, Vineis Paolo, Real Francisco X, Malats Núria, Kampman Ellen
Abstract excerpt
Surprisingly different frequencies and patterns of K-ras mutations are observed in human adenocarcinomas of the pancreas, colorectum and lung. Their respective relationships with smoking are apparently paradoxical. We evaluated all the available types of clinical and epidemiological studies on the relationship between tobacco smoking and the occurrence of K-ras mutations in human adenocarcinomas of the pancreas,...
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