Article
Serum concentrations of organochlorine compounds and K-ras mutations in exocrine pancreatic cancer. PANKRAS II Study Group.
Lancet (London, England) - 1 Jan 2000
Porta M, Malats N, Jariod M, Grimalt J O, Rifà J, Carrato A, Guarner L, Salas A, Santiago-Silva M, Corominas J M, Andreu M, Real F X
Abstract excerpt
BACKGROUND: Organochlorine compounds such as 1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane (p,p'-DDT), 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene (p,p'-DDE), and some polychlorinated biphenyls (PCBs) are carcinogenic to animals and possibly also to human beings. Occupational exposure to DDT may increase the risk of pancreas cancer. The high frequency of K-ras mutations in pancreatic cancer remains...
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