Article
Apc mutation enhances PyMT-induced mammary tumorigenesis.
PloS one - 1 Jan 2011
Prosperi Jenifer R, Khramtsov Andrey I, Khramtsova Galina F, Goss Kathleen H
Abstract excerpt
The Adenomatous Polyposis Coli (APC) tumor suppressor gene is silenced by hypermethylation or mutated in up to 70% of human breast cancers. In mouse models, Apc mutation disrupts normal mammary development and predisposes to mammary tumor formation; however, the cooperation between APC and other mutations in breast tumorigenesis has not been studied. To test the hypothesis that loss of one copy of APC promotes...
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