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Article

De Novo Synthesis of VP16 Coordinates the Exit from HSV Latency In Vivo

26 Mar 2009

Abstract excerpt

The mechanism controlling the exit from herpes simplex virus latency (HSV) is of central importance to recurrent disease and transmission of infection, yet interactions between host and viral functions that govern this process remain unclear. The cascade of HSV gene transcription is initiated by the multifunctional virion protein VP16, which is expressed late in the viral replication cycle. Currently, it is...

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PMID: 19325890
DOI: 10.1371/journal.ppat.1000352

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