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Article

Latent infection can be established with drastically restricted transcription and replication of the HSV-1 genome.

Virology - 1 Feb 1993

Sedarati F, Margolis T P, Stevens J G

Abstract excerpt

Viral functions essential for the establishment of latent infection in murine sensory neurons in vivo were investigated by employing a herpes simplex virus type 1 (HSV-1) variant (KD6/B11) deleted for expression of the ICP4 gene and therefore unable to replicate. Since the viral DNA persisted in these cells, the latency-associated transcripts were expressed for prolonged periods of time, and the variant was...

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Identifiers

PMID: 8380670
DOI: 10.1006/viro.1993.1089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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