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Article

Evidence that herpes simplex virus VP16 is required for viral egress downstream of the initial envelopment event.

Journal of virology - 1 Jul 2000

Mossman K L, Sherburne R, Lavery C, Duncan J, Smiley J R

Abstract excerpt

During infection with herpes simplex virus type 1 (HSV-1), VP16 serves multiple functions, including transcriptional activation of viral immediate early genes and downregulation of the virion host shutoff protein vhs. Furthermore, VP16 has been shown to be involved in some aspect of virus assembly and/or maturation. Experiments with a VP16 null virus, 8MA, suggested that VP16 plays a direct role in virion...

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Identifiers

PMID: 10864638
DOI: 10.1128/jvi.74.14.6287-6299.2000
PMCID: PMC112134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence that herpes simplex virus VP16 is required for viral egress downstream of the initial envelopment event.PMID 10864638Read ↗

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