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Article

LRP/LR as an alternative promising target in therapy of prion diseases, Alzheimer's disease and cancer.

Infectious disorders drug targets - 1 Feb 2009

Vana Karen, Zuber Chantal, Pflanz Heike, Kolodziejczak Dominika, Zemora Georgeta, Bergmann Ann-Katrin, Weiss Stefan

Abstract excerpt

The 37 kDa/67 kDa laminin receptor (LRP/LR) represents a key player for cell adhesion, is associated with the metastatic potential of solid tumors and is required for maintenance of cell viability by preventing apoptosis. LRP/LR acts as a receptor for viruses such as Sindbis virus, Venezuelean Equine Encephalitis (VEE) virus, Adeno-associated-viruses (AAV) and Dengue Virus, the latter causing 50 to 100 million...

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Identifiers

PMID: 19200017
DOI: 10.2174/1871526510909010069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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LRP/LR as an alternative promising target in therapy of prion diseases, Alzheimer's disease and cancer.PMID 19200017Read ↗

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Emerging roles of the cellular prion protein (PrPC) and 37/67 kDa laminin receptor (RPSA) interaction in cancer biologySemantic proximity Read ↗

Scrapie-infected transgenic mice expressing a laminin receptor decoy mutant reveal a prolonged incubation time associated with low levels of PrPres.Semantic proximity Read ↗

Delivery of single-chain antibodies (scFvs) directed against the 37/67 kDa laminin receptor into mice via recombinant adeno-associated viral vectors for prion disease gene therapySemantic proximity Read ↗

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