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Article

Cell surface accumulation of a truncated transmembrane prion protein in Gerstmann-Straussler-Scheinker disease P102L.

The Journal of biological chemistry - 5 Jul 2002

Mishra Ravi Shankar, Gu Yaping, Bose Sharmila, Verghese Susamma, Kalepu Sudheera, Singh Neena

Abstract excerpt

A familial prion disorder with a proline to leucine substitution at residue 102 of the prion protein (PrP(102L)) is typically associated with protease-resistant PrP fragments (PrP(Sc)) in the brain parenchyma that are infectious to recipient animals. When modeled in transgenic mice, a fatal neuro...

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Identifiers

PMID: 11967261
DOI: 10.1074/jbc.M200213200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11967261-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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