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Article

Statistical theory of protein sequence design by random mutation.

The journal of physical chemistry. B - 23 Apr 2009

Bhattacherjee Arnab, Biswas Parbati

Abstract excerpt

A self-consistent mean-field based theory is developed to evaluate the site-specific amino acid pair probabilities in a library of sequences to consider the effect of correlated mutations. This approach computes the entire residue-residue substitution pattern by completely characterizing all possible residue-residue combinations consistent with a given protein structure. Design involves screening a library of...

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Identifiers

PMID: 19323540
DOI: 10.1021/jp810515s

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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