Phylogenetic spread of sequence data affects fitness of SOD1 consensus enzymes: Insights from sequence statistics and structural analyses.

doi:10.1002/prot.25486

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Article

Phylogenetic spread of sequence data affects fitness of SOD1 consensus enzymes: Insights from sequence statistics and structural analyses.

Proteins - 1 Jun 2018

Goyal Venuka Durani, Magliery Thomas J

Abstract excerpt

Non-natural protein sequences with native-like structures and functions can be constructed successfully using consensus design. This design strategy is relatively well understood in repeat proteins with simple binding function, however detailed studies are lacking in globular enzymes. The SOD1 family is a good model for such studies due to the availability of large amount of sequence and structure data motivated...

Topics

Amino Acid Sequence
Amyotrophic Lateral Sclerosis
Circular Dichroism
Consensus Sequence
Gene Expression
Humans
Mutation
Phylogeny
Protein Structure, Secondary
Static Electricity
Superoxide Dismutase-1

Source

Open in PubMed

Identifiers

PMID: 29490429
DOI: 10.1002/prot.25486

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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