GArNet: A Genetic Algorithm-Based Protein Redesign Approach to Optimize Mutation Combinations Informed by Network Theory.

Abstract excerpt

Protein redesign is an enzyme engineering strategy that enhances a template enzyme's properties by introducing mutations. Although the method is broadly employed for enzyme design, finding optimal mutation combinations with high reproducibility within a limited time frame remains a major technical hurdle. In this study, we report GArNet, a Genetic Algorithm-based protein redesign approach to optimize mutation...

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