Article
The inverse protein folding problem: self consistent mean field optimisation of a structure specific mutation matrix.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 1997
Delarue M, Koehl P
Abstract excerpt
The goal of the inverse folding problem is to supply a list of sequences compatible with a known protein structure. If two-body interactions are taken into account in energy calculations, an exhaustive exploration of the energy landscape in sequence space cannot be achieved because of the huge nu...
Topics
- Amino Acid Sequence
- Computer Simulation
- Databases as Topic
- Models, Chemical
- Models, Genetic
- Mutation
- Probability
- Protein Folding
- Proteins
- Thermodynamics