Article
The fanconi anemia core complex acts as a transcriptional co-regulator in hairy enhancer of split 1 signaling.
The Journal of biological chemistry - 15 May 2009
Tremblay Cédric S, Huard Caroline C, Huang Feng-Fei, Habi Ouassila, Bourdages Valérie, Lévesque Georges, Carreau Madeleine
Abstract excerpt
Mutations in one of the 13 Fanconi anemia (FA) genes cause a progressive bone marrow failure disorder associated with developmental abnormalities and a predisposition to cancer. Although FA has been defined as a DNA repair disease based on the hypersensitivity of patient cells to DNA cross-linking agents, FA patients develop various developmental defects such as skeletal abnormalities, microphthalmia, and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.