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Article

Cohesin-dependent regulation of Runx genes.

Development (Cambridge, England) - 1 Jul 2007

Horsfield Julia A, Anagnostou Sasha H, Hu Jimmy Kuang-Hsien, Cho Kitty Hsiao Yu, Geisler Robert, Lieschke Graham, Crosier Kathryn E, Crosier Philip S

Abstract excerpt

Runx transcription factors determine cell fate in many lineages. Maintaining balanced levels of Runx proteins is crucial, as deregulated expression leads to cancers and developmental disorders. We conducted a forward genetic screen in zebrafish for positive regulators of runx1 that yielded the cohesin subunit rad21. Zebrafish embryos lacking Rad21, or cohesin subunit Smc3, fail to express runx3 and lose...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17567667
DOI: 10.1242/dev.002485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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