Article
GIGYF2 has no major role in Parkinson genetic etiology in a Belgian population.
Neurobiology of aging - 1 Feb 2011
Meeus Bram, Nuytemans Karen, Crosiers David, Engelborghs Sebastiaan, Pals Philippe, Pickut Barbara, Peeters Karin, Mattheijssens Maria, Corsmit Ellen, Cras Patrick, De Deyn Peter Paul, Theuns Jessie, Van Broeckhoven Christine
Abstract excerpt
Missense mutations were identified in the Grb10-Interacting GYF Protein-2 gene (GIGYF2), located in the chromosomal region 2q36-q37, in familial Parkinson disease (PD) patients of European descent. To determine the contribution of GIGYF2 mutations in an extended (N=305) Belgian series of both familial and sporadic PD patients, we sequenced all 32 coding and non-coding exons of GIGYF2. In three sporadic PD...
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