Article
PARK11 gene (GIGYF2) variants Asn56Ser and Asn457Thr are not pathogenic for Parkinson's disease.
Parkinsonism & related disorders - 1 Aug 2009
Zimprich Alexander, Schulte Claudia, Reinthaler Eva, Haubenberger Dietrich, Balzar Jörg, Lichtner Peter, El Tawil Salwa, Edris S, Foki Thomas, Pirker Walter, Katzenschlager Regina, Daniel Gerhard, Brücke Thomas, Auff Eduard, Gasser Thomas
Abstract excerpt
The GIGYF2 (Grb10-Interacting GYF Protein-2) gene has recently been proposed to be the responsible gene for the PARK11 locus. Ten different putative pathogenic variants were identified in cohorts of Parkinson's disease (PD) patients from Italy and France. Among these variants Asn56Ser and Asn457Thr were found repeatedly. In the present study we screened 669 PD patients (predominantly of central European origin)...
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