Article
Non-synonymous GIGYF2 variants in Parkinson's disease from two Asian populations.
Human genetics - 1 Sept 2009
Tan Eng-King, Lin Chin-Hslen, Tai Chun-Hwei, Tan Louis C, Chen Meng-Ling, Li R, Lim Hui-Qin, Pavanni Ratnagopal, Yuen Yih, Prakash K M, Zhao Yi, Wu Ruey-Meei
Abstract excerpt
Mutations in the GIGYF2 gene at the PARK11 locus have recently been reported in Parkinson's disease (PD). However, the pathogenicity of some of these mutations has been debated. We conducted a comprehensive genetic analysis of the entire GIGYF2 gene in a cohort of young onset and familial PD patients, followed up with screening of specific variants in a separate group of PD and healthy controls. A total of 850...
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