Article
No evidence for pathogenic role of GIGYF2 mutation in Parkinson disease in Japanese patients.
Neuroscience letters - 2 Aug 2010
Li Lin, Funayama Manabu, Tomiyama Hiroyuki, Li Yuanzhe, Yoshino Hiroyo, Sasaki Ryogen, Kokubo Yasumasa, Kuzuhara Shigeki, Mizuno Yoshikuni, Hattori Nobutaka
Abstract excerpt
Grb10-Interacting GYF Protein-2 (GIGYF2) is a candidate gene for PARK11 locus. To date, seven different GIGYF2 missense mutations have been identified in patients with familial Parkinson disease (PD) of European descent. To clarify the pathogenic role of GIGYF2 in PD, we analyzed the frequency of GIGYF2 mutations in 389 Japanese patients with PD (including 93 patients with late-onset familial PD, 276 with...
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