Article
Mutational screening and zebrafish functional analysis of GIGYF2 as a Parkinson-disease gene.
Neurobiology of aging - 1 Nov 2011
Guella Ilaria, Pistocchi Anna, Asselta Rosanna, Rimoldi Valeria, Ghilardi Anna, Sironi Francesca, Trotta Luca, Primignani Paola, Zini Michela, Zecchinelli Anna, Coviello Domenico, Pezzoli Gianni, Del Giacco Luca, Duga Stefano, Goldwurm Stefano
Abstract excerpt
The Grb10-Interacting GYF Protein-2 (GIGYF2) gene has been proposed as the Parkinson-disease (PD) gene underlying the PARK11 locus. However, association of GIGYF2 with PD has been challenged and a functional validation of GIGYF2 mutations is lacking. In this frame, we performed a mutational screening of GIGYF2 in an Italian PD cohort. Exons containing known mutations were analyzed in 552 cases and 552 controls....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.