Article
Glycosyltransferase B4GALNT1 and type 1 diabetes in Croatian population: clinical investigation.
Clinical biochemistry - 1 Jun 2009
Boraska Vesna, Torlak Vesela, Skrabić Veselin, Kacić Zrinka, Jaksić Jasminka, Stipancić Gordana, Uroić Anita Spehar, Markotić Anita, Zemunik Tatijana
Abstract excerpt
OBJECTIVES: Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by destruction of pancreatic beta cells. Gangliosides are thought to be a target of a variety of anti-islet autoantibodies. The formation of gangliosides is catalyzed by addition of sugar residues to complex glycoconjugate molecules by glycosyltransferases. Beta-1,4-N-acetyl-galactosaminyl transferase 1 is the enzyme involved in...
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