Article
Natural genetic variation in transcriptome reflects network structure inferred with major effect mutations: insulin/TOR and associated phenotypes in Drosophila melanogaster.
BMC genomics - 24 Mar 2009
Nuzhdin Sergey V, Brisson Jennifer A, Pickering Andrew, Wayne Marta L, Harshman Lawrence G, McIntyre Lauren M
Abstract excerpt
BACKGROUND: A molecular process based genotype-to-phenotype map will ultimately enable us to predict how genetic variation among individuals results in phenotypic alterations. Building such a map is, however, far from straightforward. It requires understanding how molecular variation re-shapes developmental and metabolic networks, and how the functional state of these networks modifies phenotypes in genotype...
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