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Article

Late endocytic dysfunction as a putative cause of amyloid fibril formation in Alzheimer's disease.

Journal of neurochemistry - 1 Jun 2009

Yuyama Kohei, Yanagisawa Katsuhiko

Abstract excerpt

The assembly of amyloid beta-protein to amyloid fibrils is a critical event in Alzheimer's disease. Evidence exists that endocytic pathway abnormalities, including the enlargement of early endosomes, precede the extraneuronal amyloid fibril deposition in the brain. We determined whether endocytic dysfunction potently promotes the assembly of amyloid beta-protein on the surface of cultured cells. Blocking the...

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Identifiers

PMID: 19317854
DOI: 10.1111/j.1471-4159.2009.06046.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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