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Identification of Antimalarial Compounds that Inhibit Apicomplexan AP2 Proteins in the Human Malaria Parasite <i>Plasmodium falciparum</i>

2022-04-06

Abstract excerpt

Plasmodium parasites are reliant on the Apicomplexan AP2 (ApiAP2) transcription factor family to regulate gene expression programs. AP2 DNA binding domains have no homologs in the human or mosquito host genomes, making them potential antimalarial drug targets. Using an in-silico screen to dock thousands of small molecules into the crystal structure of the AP2-EXP (Pf3D7_1466400) AP2 domain (PDB:3IGM), we identifi...

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Literature Corpus work
b7f60246-327d-5c32-af68-811941e9cfdf
DOI
10.1101/2022.04.05.487101
Open publication

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