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Article

Selective inhibition of PARP10 using a chemical genetics strategy.

Bioorganic & medicinal chemistry letters - 1 Nov 2015

Morgan Rory K, Carter-O'Connell Ian, Cohen Michael S

Abstract excerpt

The lack of inhibitors that are selective for individual poly-ADP-ribose polymerase (PARP) family members has limited our understanding of their roles in cells. Here, we describe a chemical genetics approach for generating selective inhibitors of an engineered variant of PARP10. We synthesized a series of C-7 substituted 3,4-dihydroisoquinolin-1(2H)-one (dq) analogues designed to selectively inhibit a mutant of...

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Source

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Identifiers

PMID: 26231158
DOI: 10.1016/j.bmcl.2015.07.033
PMCID: PMC4607647

Genes

PARP10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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