Article
Evaluation of RAD50 in familial breast cancer predisposition.
International journal of cancer - 1 Jun 2006
Tommiska Johanna, Seal Sheila, Renwick Anthony, Barfoot Rita, Baskcomb Linda, Jayatilake Hiran, Bartkova Jirina, Tallila Jonna, Kaare Milja, Tamminen Anitta, Heikkilä Päivi, Evans D Gareth, Eccles Diana, Aittomäki Kristiina, Blomqvist Carl, Bartek Jiri, Stratton Michael R, Nevanlinna Heli, Rahman Nazneen
Abstract excerpt
The genes predisposing to familial breast cancer are largely unknown, but 5 of the 6 known genes are involved in DNA damage repair. RAD50 is part of a highly conserved complex important in recognising, signalling and repairing DNA double-strand breaks. Recently, a truncating mutation in the RAD50 gene, 687delT, was identified in 2 Finnish breast cancer families. To evaluate the contribution of RAD50 to familial...
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