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Article

RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability.

Carcinogenesis - 1 Aug 2006

Heikkinen Katri, Rapakko Katrin, Karppinen Sanna-Maria, Erkko Hannele, Knuutila Sakari, Lundán Tuija, Mannermaa Arto, Børresen-Dale Anne-Lise, Borg Ake, Barkardottir Rosa B, Petrini John, Winqvist Robert

Abstract excerpt

The Mre11 complex, composed of RAD50, NBS1 and MRE11, has an essential role in the maintenance of genomic integrity and preventing cells from malignancy. Here we report the association of three Mre11 complex mutations with hereditary breast cancer susceptibility, studied by using a case-control design with 317 consecutive, newly diagnosed Northern Finnish breast cancer patients and 1000 geographically matched...

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Source

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Identifiers

PMID: 16474176
DOI: 10.1093/carcin/bgi360
PMCID: PMC3006189

Genes

RAD50
BRCA1
MRE11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability.PMID 16474176Read ↗

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Rad50 c.687delT does not contribute significantly to familial breast cancer in a French population.Semantic proximity Read ↗

Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex.Semantic proximity Read ↗

Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study.Semantic proximity Read ↗

Exome sequencing identified rare recurrent copy number variants and hereditary breast cancer susceptibility.Semantic proximity Read ↗

Germline pathogenic variants in the MRE11, RAD50, and NBN (MRN) genes in cancer predisposition: A systematic review and meta-analysis.Semantic proximity Read ↗

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Importance of Germline and Somatic Alterations in Human MRE11, RAD50, and NBN Genes Coding for MRN ComplexSemantic proximity Read ↗

Human RAD50 deficiency: Confirmation of a distinctive phenotype.Semantic proximity Read ↗

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