Article
KIR2DL4 (CD158d) polymorphisms and susceptibility to multiple sclerosis.
Journal of neuroimmunology - 29 May 2009
Goris An, Dobosi Rita, Boonen Steven, Nagels Guy, Dubois Bénédicte
Abstract excerpt
Several lines of evidence implicate CD56(bright) NK cells in the pathogenesis of multiple sclerosis (MS). This proposed immunoregulatory pathway involves already established susceptibility genes such as interleukin-2 receptor alpha (IL2RA) and interleukin-7 receptor (IL7R). We therefore investigated the CD56(bright) NK cell effector molecule KIR2DL4 for its involvement in genetic susceptibility to MS in a study...
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