Article
Implications of EGFR inhibition in ovarian cancer cell proliferation.
Gynecologic oncology - 1 Jun 2008
Bull Phelps Shawna L, Schorge John O, Peyton Michael J, Shigematsu Hisayuki, Xiang Li-Lin, Miller David S, Lea Jayanthi S
Abstract excerpt
OBJECTIVES: Epidermal Growth Factor Receptor (EGFR) is one of the four members of the Human Epidermal Receptor (HER) family and is over-expressed in multiple malignancies. EGFR over-expression in ovarian cancer has been associated with poor prognosis. Targeted inhibition of EGFR via its tyrosine kinase domain is a successful treatment in lung cancer. Our objective was to correlate EGFR over-expression and growth...
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