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Article

Muscle-specific VEGF deficiency greatly reduces exercise endurance in mice.

The Journal of physiology - 15 Apr 2009

Olfert I Mark, Howlett Richard A, Tang Kechun, Dalton Nancy D, Gu Yusu, Peterson Kirk L, Wagner Peter D, Breen Ellen C

Abstract excerpt

Vascular endothelial growth factor (VEGF) is required for vasculogenesis and angiogenesis during embryonic and early postnatal life. However the organ-specific functional role of VEGF in adult life, particularly in skeletal muscle, is less clear. To explore this issue, we engineered skeletal muscle-targeted VEGF deficient mice (mVEGF-/-) by crossbreeding mice that selectively express Cre recombinase in skeletal...

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Source

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Identifiers

PMID: 19237429
DOI: 10.1113/jphysiol.2008.164384
PMCID: PMC2683962

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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