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Article

Chronic granulomatous disease.

Hematology/oncology clinics of North America - 1 Feb 2013

Holland Steven M

Abstract excerpt

Chronic granulomatous disease (CGD) is a paradigm for nonlymphoid primary immune defects, and has guided elucidation of oxygen metabolism in the phagocyte, vasculature, and brain. It has been in the forefront of the development of antimicrobial prophylaxis before the advent of advanced HIV and before its routine use in neutropenia. It has been an attractive target for gene therapy and bone marrow transplantation...

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PMID: 23351990
DOI: 10.1016/j.hoc.2012.11.002
PMCID: PMC3558921

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