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Article

Heterozygosity for hypoxia inducible factor 1alpha decreases the incidence of thymic lymphomas in a p53 mutant mouse model.

Cancer research - 1 Apr 2009

Bertout Jessica A, Patel Shetal A, Fryer Benjamin H, Durham Amy C, Covello Kelly L, Olive Kenneth P, Goldschmidt Michael H, Simon M Celeste

Abstract excerpt

Hypoxia inducible factors (HIF) are critical mediators of the cellular response to decreased oxygen tension and are overexpressed in a number of tumors. Although HIF1alpha and HIF2alpha share a high degree of sequence homology, recent work has shown that the two alpha subunits can have contrastin...

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Source

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Identifiers

PMID: 19293180
DOI: 10.1158/0008-5472.CAN-08-4223
PMCID: PMC2707815

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19293180-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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