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Article

Development of lymphoproliferative diseases by hypoxia inducible factor-1alpha is associated with prolonged lymphocyte survival.

PloS one - 1 Jan 2013

Sueoka Eisaburo, Sueoka-Aragane Naoko, Sato Akemi, Ide Masaru, Nakamura Hideaki, Sotomaru Yusuke, Taya Choji, Yonekawa Hiromichi, Kitagawa Tomoyuki, Kubota Yasushi, Kimura Shinya, Nakachi Kei, Tanimoto Keiji

Abstract excerpt

Hypoxia-inducible factor-1alpha (HIF-1 alpha) plays an essential role in the regulation of various genes associated with low oxygen consumption. Elevated expression of HIF-1alpha has been reported to be associated with tumor progression, invasion and metastasis in many cancers. To investigate the role of HIF-1alpha in tumor development and metastasis, we established transgenic mice constitutively expressing HIF1A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23593116
DOI: 10.1371/journal.pone.0057833
PMCID: PMC3625215

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