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Article

Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein.

The European journal of neuroscience - 1 Mar 2009

Marxreiter Franz, Nuber Silke, Kandasamy Mahesh, Klucken Jochen, Aigner Robert, Burgmayer Ralf, Couillard-Despres Sebastien, Riess Olaf, Winkler Jürgen, Winner Beate

Abstract excerpt

In familial and sporadic forms of Parkinson's disease (PD), alpha-synuclein pathology is present in the brain stem nuclei and olfactory bulb (OB) long before Lewy bodies are detected in the substantia nigra. The OB is an active region of adult neurogenesis, where newly generated neurons physiologically integrate. While accumulation of wild-type alpha-synuclein is one of the pathogenic hallmarks of non-genetic...

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Identifiers

PMID: 19291219
DOI: 10.1111/j.1460-9568.2009.06641.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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